The Laboratory of Molecular Physiology on Energy Metabolism was established in 2008, supported by the funds from Sunny Health Holdings and Sunny Health Co., Ltd., and is in close collaboration with the Department of Metabolic Diseases. The goal of this research program is to understand the pathophysiology of overnutrition-related diseases including metabolic syndrome and diabetes, the basis of which is considered to be insulin resistance closely associated with the imbalance of energy metablism.
Project Associate Professor: Naoya Yahagi, MD, PhD
We focus on the molecular mechanisms of insulin resistance, especially from the standpoint of lipid metabolism.
For the better understanding of the basic pathogenesis of overnutrition and insulin resistance, we are proposing a new concept of "adipose capacity"; insulin resistance can be considered as a physiological response against the overload of nutrients beyond the "adipose capacity". To clarify the molecular basis of this concept is one of our major goals.